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pentobarbital will lessen the level or impact of sildenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Potent CYP3A4 inducers are envisioned to induce substantial decreases in sildenafil plasma amountspentobarbital will lessen the level or result of bosentan by impacting hepatic/intestinal enzyme CYP3